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专利名称：PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENEREATION ANDINHIBITORS FOR PROTECTING CELLS
发明人：AMBATI, Jayakrishna,TARALLO, Valeria申请号：EP12814249.4申请日：20120716公开号：EP2734240B1公开日：20180321
摘要：A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor ofMyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), canbe therapeutically useful in the context of age-related macular degeneration andgeographic atrophy.
申请人：UNIV OF KENTUCKY RESEARCH FOUNDATION
地址：US
国籍：US
代理机构：Henderson, Helen Lee
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